In vivo experiments showed that combination of anti-MMP-9 and anti-PDL1 induced TCR diversity, increased CD3+ T cells(including memory/effector CD4 and CD8 T cells), suggesting that inhibition of MMP-9 increased T-helper cell 1 type cytokines, induced delivery of effector/memory T cells to tumor tissues (120). This evidence concerns the gene CD4 and neoplasm.