MMP1 and laryngotracheoesophageal cleft: However, a meta-analysis including 825 Han Chinese patients with LC showed no significant association between MMP1-1607 2G carriers and MMP1-1607 1G/1G, besides, another study showed that MMP1-1607 1G/2G and 2G/2G genotype (2G carriers) presented a lack of association with LC risk (OR = 1.04[95% CI = 0.68–1.58]and OR = 0.99[95% CI = 0.71–1.40], respectively), all of these results are consistent with the conclusion concluded by Xiao, X.Y etc. (34, 127, 139, 145)(Table 4).