In NSCLC cells, Curcumin(derived from the plant Curcuma longa) combined with carboplatin significantly inhibited tumor growth, cell migration, and invasion by effectively inhibiting MMP-2/9 expression, indicating that targeting MMP-2/9 and decreasing their expression and activities were potential effective way to enhance carboplatin sensitivity in patients with NSCLC (54). Here, MMP2 is linked to non-small cell lung carcinoma.