Four variants of FKBP5 (rs9296158, rs3800373, rs1360780, and rs9470080) have been found to interact with childhood trauma through G×E interactions to significantly increase the risk of developing PTSD[50, 54, 99, 100, 101, 102, 103] (Table 1). The gene discussed is FKBP5; the disease is post-traumatic stress disorder.