CRP and cardiovascular disorder: However, MR studies have not found evidence of a potential causal relationship between EM and a number of cardiovascular diseases, including atrial fibrillation, coronary artery disease, heart failure, ischemic stroke, stroke and its subtypes (small vessel stroke, large-artery atherosclerotic stroke, and cardioembolic stroke), as well as some cardiovascular disease risk factors, such as cholesterol levels, fasting glucose, glycosylated hemoglobin A1c, C reactive protein and apolipoprotein levels (41, 76–78).