reported that older ANM was significantly associated with an elevated risk of all intrinsic subtypes of BC, including estrogen receptor (ER)+, ER-, luminal A-like [ER+ and/or progesterone receptor (PR)+, human epidermal growth factor receptor 2 (HER2)-, grade 1 and 2], luminal B-like (ER+ and/or PR+, HER2+), HER2-enriched-like (ER- and PR-, HER2+) BC, except triple-negative BC (ER-, PR-, HER2-) (115). This evidence concerns the gene ESR1 and breast cancer.