TCF4 and cardiomyopathy: Comparison of the regulon activity between HCM and NC identified activation of transcription factors (TFs) in HCM including KLF5 which was associated with cardiomyopathy,21, 22ETV1 which is involved in atrial remodelling,23, 24 and TCF4 which participates in the WNT signalling pathway (Figure 3B,C).