As shown in Figure 6, the results of α diversity analysis showed that the Shannon and CHAO1 index of AOM/DSS, SR‐B1−/+ mice were significantly increased compared with C57 mice (p < 0.05), while that of AOM/DSS + SR‐B1−/+ mice were significantly reduced compared with AOM/DSS mice (p < 0.05). Here, SCARB1 is linked to infectious otitis media.