As shown in Figure 5, compared with AOM/DSS mice, the AOM/DSS + SR‐B1−/+, anti‐PD1, anti‐PD1 + SR‐B1−/+ mice had a significantly higher final body weight (p < 0.01), and the tumor load in AOM/DSS + SR‐B1−/+ and anti‐PD1 + SR‐B1−/+ mice was significantly reduced (p < 0.05). The gene discussed is SCARB1; the disease is infectious otitis media.