The western blot shown that compared with the AOM/DSS mice, the expression of SR‐B1, LDL‐R in AOM/DSS + SR‐B1−/+, anti‐PD1 + SR‐B1−/+ mice colorectal tissue reduced significantly (p < 0.05), while the expression of ABCA1 in anti‐PD1 + SR‐B1−/+ mice colorectal tissue increased significantly (p < 0.05). The gene discussed is SCARB1; the disease is infectious otitis media.