Compared with AOM/DSS mice, the abundances of Akkermansia, Parabacteroides and Romboutsia were significantly increased (p < 0.05), while the abundance of Desulfovibrio, Muribaculum, and Lachnoclostridium was significantly reduced in AOM/DSS + SR‐B1−/+ mice (p < 0.05). Here, SCARB1 is linked to infectious otitis media.