In this study, SR‐BI deficiency reduced the tumor load, and the abundances of Akkermansiaceae, Parabacteroides, and Romboutsia were significantly increased in AOM/DSS+SR‐B1−/+ mice; the abundances of Desulfovibrio, Muribaculum, and Lachnoclostridium were apparently reduced. This evidence concerns the gene SCARB1 and infectious otitis media.