Compared with the AOM/DSS mice, the expression of PD‐L1 in AOM/DSS + SR‐B1−/+, anti‐PD1, and anti‐PD1 + SR‐B1−/+ mice colorectal tissue reduced significantly (p < 0.05), while the expression of HLA‐B in anti‐PD1 and anti‐PD1 + SR‐B1−/+ mice colorectal tissue increased significantly (p < 0.05). The gene discussed is RPL17; the disease is infectious otitis media.