The immunohistochemical staining showed that compared with the AOM/DSS mice, the level of Ki67+, PCNA in AOM/DSS + SR‐B1−/+ mice was significantly reduced, while the level of CASP3 was significantly increased (p < 0.01), which indicated that SR‐B1 knockdown inhibits the growth of tumor cells. This evidence concerns the gene SCARB1 and infectious otitis media.