Even when SARS-CoV-2 is equipped to counteract SERINC5 [19,46], we would expect a defect in replication since SERINC5 was already present in our cells prior to the infection and the subsequent synthesis of ORF7a and svRNAs—the SERINC5 antagonists in SARS-CoV-2. Here, SERINC5 is linked to infection.