Interestingly, in both the HIV vs. HIV+PSU and WT+PSU vs. HIV+PSU comparisons, Tnnc1, Tnnt2, and Actc1 were found to be majorly involved in the calcium signaling and dilated cardiomyopathy (DCM) signaling pathways. This evidence concerns the gene ACTC1 and familial dilated cardiomyopathy.