In our cohort of AHI, we observed differences relative to HD in CD4+ and CD8+ T cells (i.e., naïve cells reduction, an increase in EM and markers of activation and exhaustion on CD8+ T cells) [23,24], and changes after 1-year of ART (i.e., a decrease in activation and exhaustion markers on CD8+ T cells), underlying the beneficial effect of antiviral therapy on the immune system [25]. The gene discussed is CD8A; the disease is Huntington disease.