Significant predictors for severe disease (stages IIB and III) according to clinical-therapeutic staging as proposed by Siddiqi and Mehra included high ferritin, LDH, CRP, a patient age of above 75 years, AEP, and comorbidities, including cardiovascular diseases, lung diseases, diabetes mellitus, and the presence of two or more comorbidities (Table 3). This evidence concerns the gene CRP and lung disorder.