CD209 and infection: This may provide some credence to the idea that allosteric and conformational variations make certain spike glycans particularly vulnerable to DC-SIGN recognition and that S1-domain glycans that are neither proximal to the RBD nor present on the periphery of the SARS-CoV-2 spike are uniquely suited to facilitate DC-SIGN-mediated trans-infection (Figure 2A,B and Figure 3C).