Interestingly, notable exceptions to this were N74 and N149: even though these glycans were distal to the SARS-CoV-2 spike RBD, the N74Q and N149Q pseudoviral mutants did not display attenuated DC-SIGN-mediated trans-infectivity, with trans-infection signals at 26.0% and 28.4% of direct-infection signal, respectively. Here, CD209 is linked to infection.