Because the SARS-CoV-2 spike has been shown to bind to a multitude of cell surface molecules—including sialic-acid-binding surface receptors, heparan sulfate, glycosphingolipids and more—it is plausible that the predicted unique structural dynamics of the Omicron BA.2 strain spike could confer resistance to mannan-mediated inhibition of trans-infection, as well as some ability to be captured by a fibroblast cell line that did not express DC-SIGN [42,82,83]. Here, CD209 is linked to infection.