Authors have also showed that in the presence of high levels of trypsin, some of the spike proteins of Clade II viruses were capable of mediating infection and replication in human (including Caco-2 intestine cell line) and bat intestine primary cells while TMPRSS2 and furin endogenous proteases had no effect on Clade II virus entry [42]. Here, TMPRSS2 is linked to infection.