Therefore, to evaluate the involvement of the mannose–lectin interaction on SARS-CoV-2 infection, we performed an antiviral assay in the presence or absence of D-(+)-mannose, using Vero E6 and A549 cells, in order to evaluate its role on the antiviral activity of lectins ConBR and DVL, in a general infection and virucidal assays. This evidence concerns the gene DVL1 and infection.