However, infection of CRISPR/Cas-generated CD46 knockout cells based on different kidney epithelial cells (slow phase eye velocity (SPEV) and PK-15 cells) and 38A1D lymphoma cells, which are naturally deficient for CD46, confirmed the CD46-independent entry, illustrating that CD46 is not an essential determinant of host cell entry for CSFV [67]. Here, CD46 is linked to infection.