BCL9 and B-cell acute lymphoblastic leukemia: BCL9 oncogene, a member of the Wnt signaling pathway, are aberrantly expressed in human multiple myeloma (MM) and colon carcinoma [50] and overexpressed following t(1;14)(q21;q32)/BCL9-IGH in pre-B-cell acute lymphoblastic leukemia (ALL) [51].