ACE2 and injury: Finally, the gender difference might be a consequence of the dissimilar immune response, with males showing higher circulating concentration of Angiotensin-Converting Enzyme II (ACE2) [32], leading to increased viral binding to ACE2, higher levels of Angiotensin II and consequent pulmonary vasoconstriction, inflammation and oxidative organ damage, ultimately promoting higher risk of acute lung injury [3].