In this study, we explored the contribution of additional known functional innate immune gene polymorphisms, namely, TLR2-rs5743708, TLR4-rs4986790, TLR4-rs4986791, CD14-rs2569190, CARD8-rs1834481, IL18-rs2043211, and CD40-rs1883832, in COVID-19 phenotype and prognosis since data on these polymorphisms are either limited or missing. The gene discussed is CARD8; the disease is COVID-19.