The RTS,S/AS01Ε (RTS,S), the most advanced of the subunit malaria vaccines, is a pre-erythrocytic P. falciparum vaccine that consists of a protein (RTS) of the NANP repeat and C-terminal portions (R and T, respectively) of the NF54 strain of P. falciparum CSP, fused with the hepatitis B virus surface antigen (HBsAg; the S portion). The gene discussed is DNAJC5; the disease is malaria.