VEGFA and dry age related macular degeneration: Therefore, the mechanism of action of DHA in early and intermediate dry AMD treatments is thought to involve the suppression of drusen genesis via mTORC inhibition, the alteration of the function of macrophages toward an anti-inflammation phenotype by inhibiting proinflammatory cytokine production, and the mediation of anti-neovascularization effects by inhibiting the effects of VEGF in the choroid and retina.