PTPN1 and cancer: The polybromodiphenyl ether, compound 96 (IC50 = 0.85 μM, Figure 20), which was isolated from the Indonesian marine sponge Lamellodysidea herbacea, was found to be a potent PTP1B inhibitor, with an IC50 value in the low-micromolar range, but it resulted in cytotoxicity against two human cancer cell lines (HCT-15 and Jurkat cells).