Mutations in the gene encoding ALK have been linked to multiple cancers, including the nucleophosmin (NPM1)-ALK fusion oncoprotein observed in anaplastic large-cell lymphoma (ALCL) and the echinoderm microtubule-associated protein-like 4 (EML4)-ALK in non-small-cell lung cancer (NSCLC), which significantly contribute to tumor cell cycle progression, migration, and evasion of apoptosis [2,3,4,5,6,7]. The gene discussed is NPM1; the disease is cancer.