In addition, HO-1 can promote tumor angiogenesis, cell proliferation, invasion, and metastasis, etc., and is highly expressed in various malignant tumors, including prostate cancer, kidney cancer, breast cancer, lung cancer, liver cancer, pancreatic cancer, melanoma, and especially in gynecological cancers (ovarian cancer, etc.)[30]. This evidence concerns the gene HMOX1 and familial pancreatic carcinoma.