Tetrahydrocurcumin can inhibit the melanin production in B16F10 melanoma cells induced by melanocyte-stimulating hormone (α-MSH), and modulate the expressions of important cellular enzymes, tyrosinase, tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2), which involved the biosynthetic production of melanin [26]. The gene discussed is TYRP1; the disease is melanoma.