AKT1 and colonic neoplasm: In addition, salvianolic acid B can activate the expression of autophagy-associated proteins light chain 3-II type (LC3-II) and autophagy-associated protein 5 homolog (Atg5) in HCT116 colon cancer cells by inhibiting the protein kinase B (Akt)/mammalian rapamycin target protein (mTOR) signaling pathway.