PKM and non-small cell lung carcinoma: In the NSCLC cell lines NCI-H2030 and NCI-H1650, salvianolic acid B can inhibit pyruvate kinase M2 (PKM2)-mediated metabolic reprogramming, downregulate the expression of the metabolic reprogramming-related genes lactate dehydrogenase A (LDHA) and glucose transporter 1 (GLUT1), and inactivate EMT (markedly reduced transcription factors β-catenin expression as well as elevated transmembrane glycoproteins E-cadherin expression), thereby attenuating the metastasis of NSCLC [38].