Salvianolic acid B reduced the damage of cardiomyocyte H9c2 glyoxylation deprivation reperfusion, improved cardiac function, reduced myocardial infarct size, decreased myocardial injury markers and inflammation-related factors, and reduced myocardial apoptosis in ischemia/reperfusion of the left anterior descending branch of the ligated coronary artery in rats by upregulating myocardial SIRT1 expression, inducing nuclear translocation, inhibiting high mobility histone box 1 (HMGB1) secretion, and inhibiting the TLR4/NF-kB signaling pathway [79]. This evidence concerns the gene HMGB1 and ischemia.