TGFB1 and Hepatic fibrosis: In mouse models of senecionine-induced acute liver injury, salvianolic acid B can regulate oxidative stress (increased SOD levels and decreased GSH levels) and inhibit liver fibrosis-related factors, including MMP-9, TGF-β1, and phosphorylated STAT3, by modulating the coagulation system (decreased expression of plasminogen activator inhibitor 1 (PAI-1)).