In ID8 ovarian cancer cells, salvianolic acid B inhibited cell proliferation not only by downregulating the PI3K/Akt signaling pathways of six proteins, namely PI3K110β, PDPK1, p-PDPK1 (Ser241), pan-Akt, p-Akt1 (Ser473), and p-GSK3β (Y216), but also by downregulating the protein expression of phosphorylation (p)-IκBα/IκBα and p-p65/p65 of the nuclear factor kappa-B (NF-κB) signaling pathway. This evidence concerns the gene NFKBIA and ovarian carcinoma.