In these mice, salvianolic acid B blocked platelet-derived growth factor-B signaling by inhibiting the phosphorylation of platelet-derived growth factor receptor-β, inhibited the action of tumor cells on perivascular cells, promoted the structural integrity of tumor vessels, increased perivascular cell coverage (elevated αSMA+ and NG2+), promoted basement membrane integrity (elevated collagen IV+), enhanced tight junctions between endothelial cells, reduced vascular leakage, and promoted normalization of tumor vessels, eventually inhibiting tumor metastasis [44]. The gene discussed is ACTA1; the disease is neoplasm.