STAT3 and cancer: In addition, salvianolic acid B can specifically bind to mortalin, which is highly expressed in many cancers, and increase the degradation of mortalin proteasomes through ubiquitination, which upregulates reversion-inducing cysteine-rich protein with Kazal motifs (RECK) and inhibits signal transducer and activator of transcription 3 (STAT3), thereby reversing EMT and attenuating the migratory and invasive potential of HepG2 and HCCLM3 hepatocellular carcinoma cells [40].