TGFB1 and Hepatic fibrosis: Remarkably, the multiple bioactivities of salvianolic acid B are closely associated with its ability to activate the AMPK, SIRT1, Nrf2/HO-1, and FGF19/FGFR4 signaling pathways; inhibit the TGF-β/Smad, MAPK, and NF-κB/IκB signaling pathways; regulate oxidative stress; and inhibit apoptosis, inflammation, and the expression of liver fibrosis-related factors.