TGFB1 and Hepatic fibrosis: In rat models of carbon-tetrachloride-induced liver fibrosis, salvianolic acid B exerts anti-fibrotic effects by downregulating TGF-β1, inhibiting the hedgehog signaling pathway, and reducing the expression of hedgehog signaling pathway-related genes, including Sonic hedgehog (Shh), membrane protein receptor protein patched homolog 1 (Ptch1), membrane protein receptor smoothened (Smo), and transcription factor glioma-associated oncogene homolog 1 (Gli1), thereby inhibiting the activation of HSCs, which are key cells involved in the development of a fibrotic environment [164].