After 36 repositionable drugs were administrated to chimeric mice, microarray on human genes was performed and indicated that gene expression analysis was an appropriate method for screening for medicines that were effective for liver fibrosis and that LET inhibited YAP, CTGF, and TGF-β expressions and activated CYP26A1 expressions in humanized hepatocytes in chimeric mice; moreover, it ameliorated liver fibrosis in two liver fibrosis mouse models [49]. Here, CCN2 is linked to Hepatic fibrosis.