Indeed, our prior research has established a correlation between increased concentrations of pro-inflammatory cytokines, such as interleukin-6 (IL-6) and interleukin-1 (IL-1), and the occurrence of neurotoxicity and cognitive impairment subsequent to prolonged exposure to CMF, which is a combination of cyclophosphamide (CYP), methotrexate (MTX), and 5-fluorouracil (5-FU) [5]. The gene discussed is IL6; the disease is Cognitive impairment.