In the current study, we discovered that soluble neuropeptides and neurotrophins from pig brain retard the progressive development of AD pathological hallmarks in the 3xTg-APP/Bin1/COPS5 (3xTg-AD) mouse model of AD based on the interaction between natriuretic peptides and AD-associated pathways [16,17]. This evidence concerns the gene COPS5 and Alzheimer disease.