Immunohistochemistry using specific antibodies against microglia (CD11b) and astroglia (GFAP), in all mice groups (Figure 4 and Figure 5), showed that Nosustrophine significantly reduced the density of activated microglia (Figure 4A,C) and astrogliosis (Figure 5A,C) in 3xTg-AD mice. This evidence concerns the gene ITGAM and Alzheimer disease.