Given the results, the fact that some types of intervention are predicted to be specifically beneficial in certain situations (e.g., SGLT2 inhibition indicating a benefit in most patients with a high risk of HF and CKD events, but not in subjects with a high risk of CAD events), and that this observation is in very good agreement with the observations in the intervention trials reported, further supports the validity of the approach. This evidence concerns the gene SLC5A2 and hydrops fetalis.