IL25 and neoplasm: Notably, effects on the PI3K/Akt/mTOR signaling pathway have been observed [41], along with the inhibition of Top 1 DNA relaxation activity [52], suppression of SIRT3 histone deacetylase [53], mitigation of tumor cell metastasis as demonstrated in in vivo mouse assays [42], facilitation of the tumor resection process via bioluminescence monitoring [42,51,52,53], and anti-metastatic effects underscored by interleukin-25 secretion from tumor-associated fibroblasts (TAF) [42].