Moreover, selenoprotein SNPs can modify the risk of prostate cancer and are associated with risk factors such as Gleason score, stage, grade, etc. Cooper et al. [103] revealed that men homozygous for selenoprotein P-Ala234 who were also SOD2-Ala16+ had a higher risk of prostate cancer, and this interaction was stronger in ever-smokers, where the ability to remove increased mitochondrial H2O2 is compromised, thereby promoting proliferation and migration of prostate tumor cells. This evidence concerns the gene SOD2 and Familial prostate cancer.