STAT3 and neoplasm: Another study, also using flow cytometry, as well as Western blot and real-time PCR, showed the result of cell death by apoptosis in gastric cancer cells, where silibinin increased the level of caspases-3 and -9, followed by the inhibition of the transducer of signaling and activator of transcription 3 (STAT3) pathway, which is related to tumor growth and metastasis [116].