Moving to the study of Jiang et al. in experimental cerebral ischemia/reperfusion, the investigators noted that the long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3) positively regulates the expression of AIM2 via sponging miR-485, since this miR directly binds to 3′-UTR of AIM2 to dampen its expression [90]. Here, MEG3 is linked to Cerebral ischemia.