In clinical studies, we should initially state that smoking could be an important determinant of NLRP3 inflammasome activation, as displayed in the study of Mehta et al. who found a sevenfold higher expression of NLRP3 inflammasome markers in smokers with or without coronary artery disease (CAD) compared to the respective nonsmoking groups [33]. This evidence concerns the gene NLRP3 and coronary artery disorder.