MAPT and Alzheimer disease: The etiology of AD has not been fully elucidated; however, several pathological mechanisms have been recognized in the development of the disease: the deposition of amyloid β (Aβ) plaques, hyperphosphorylation of microtubule-associated protein tau (MAPT), oxidative stress, inflammation, impaired homeostasis of bio metals, reduction in acetylcholine (ACh) levels, neuronal loss, and dysfunction of the cholinergic system [3].