AKT1 and neoplasm: The interaction between PKC and the phosphatidylinositol 3-kinase (PI3K)/AKT pathway is consistent with the fact that 57 interferes with AKT pathway signalling and acts through mechanisms with both direct and indirect antitumour effects, such as the direct induction of apoptosis and suppression of tumour cell proliferation, or by indirectly halting tumour-induced angiogenesis [46].