CD8A and diabetes mellitus: Regarding the CD8+ T cell analysis, we identified higher blood values in the DM-only group compared with the TB-only group, which may be explained by the high prevalence of LTBI in patients with DM, similar to other studies that found that the frequency of antigen-specific CD8+ T cells was higher in individuals with LTBI and could be associated with a protective effect to avoid the progression to active TB [12].