According to an analysis using the Reactome database, a curated database of pathways and reactions (https://reactome.org/ (accessed on 2 March 2023)), the Interferon alpha/beta signalling, including ISG20, PTPN1, IFITM1, RSAD2, MX1, ISG15, IRF9 and IFIT2 (Figure 2), was the most upregulated genes pathway in Mb04-303 infections. This evidence concerns the gene ISG15 and infection.