As was pointed out by Uebel and coworkers [118], the leptin levels in maternal plasma with a normal BMI was 9.3 ng/mL, but maternal obesity was related to a significant increase, namely for obese pregnant women with and without GDM levels were similar at 42.2 ng/mL and 46.0 ng/mL, respectively. The gene discussed is LEP; the disease is gestational diabetes.