Together with a higher BMI (25.5 kg/m2, IQR 23.4–28.7 kg/m2, vs. 21.4 kg/m2, IQR 19.7–22.9 kg/m2) and subcutaneous adipose tissue (SAT, 182 mm, IQR 158–202 mm vs. 126 mm; IQR 106–150 mm), as well as higher leptin levels, Cluster 1 showed a more diabetogenic metabolic profile with potentially higher risk for prediabetes or impaired glucose tolerance (IGT). The gene discussed is LEP; the disease is Impaired glucose tolerance.