Another Mendelian randomization study conducted by Magnus and Miliku [46] used a GRS composed of four vitamin-D-deficiency-related SNPs, including DHCR7 rs12785878, DBP/GC rs2282679, CYP24A1 rs6013897 and CYP2R1 rs1074165, as a genetic instrument with which to examine the causal effect of genetically determined vitamin D status on gestational hypertension or pre-eclampsia, but no significant associations were detected. The gene discussed is CYP2R1; the disease is preeclampsia.