In a similar case–control study by Hiraki and Qu [49], 10,061 CRC cases were genotyped for four vitamin-D-related SNPs (GC rs2282679, CYP2R1 rs10741657, DHCR7/NADSYN1 rs12785878, and CYP24A1 rs6013897) to examine the association between vD GRS and CRC risk, but no significant association was observed. Here, CYP2R1 is linked to colorectal carcinoma.