Furthermore, when adipogenesis capacity is restored through either surgical implantation of AT in a lipodystrophy mouse model [81] or pharmacological intervention with thiazolidinediones in an obesity model [82], insulin sensitivity, hyperglycaemia, and hepatic steatosis are improved or even reversed, pointing towards an extremely important role of adipogenesis in metabolic health. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.