IGHE and allergic disease: A recent article [23] suggests that the milk ladder can be used safely in individuals with (1) non-IgE-mediated allergy (excluding FPIES), (2) IgE-mediated food allergy with prior mild, non-anaphylactic reactions, (3) no diagnosis of asthma individuals, but considered for individuals with stable, treated asthma, (4) the ability to understand and comply with the instructions provided, (5) a high previous reaction threshold, (6) low or decreasing skin prick test wheal or serum specific-IgE levels; (7) younger patients or individuals of any age with limited co-existing allergies.