Decreased [Mg2+]i is also associated with pulmonary hypertension, and high Mg2+ prevents the upregulated expression of NFATc3 and its nuclear translocation, which is a major Ca2+-dependent signaling pathway that regulates the proliferation and migration of pulmonary arterial smooth muscle cells in the development of pulmonary hypertension and vascular remodeling [35]. The gene discussed is NFATC3; the disease is pulmonary arterial hypertension.