The inflammatory mediator IL-18 upregulates TRPM7 expression and currents in vascular smooth muscle cells [89], and angiotensin II and aldosterone, as mediators of hypertension and promoters of atherosclerosis, have been shown to activate TRPM7 to induce Mg2+ influx and oxidative stress production in vascular smooth muscle cells [75,79,90]. The gene discussed is TRPM7; the disease is hypertensive disorder.