SREBF1 and steatosis: On the other hand, mouse embryonic fibroblasts (MEFs) isolated from the Staggerer mice harboring a Rora-dominant negative mutation manifested higher expressions of Pparg, Cebpa, and Srebp1c than WT mice [48], and liver-specific Rora KO mice developed steatosis with elevated expressions of Fas, Scd1, Acc, and Srebp1c [63].