Two studies claimed that Irak4 (Interleukin-1 receptor associated kinase-4) controls hypoglycemia-induced glucagon secretion by modulating hypothalamic Il-1β signaling, and Agpat5 activation in AgRP (agouti-related protein) neurons leads to hypoglycemia-induced glucagon secretion [70,71]. The gene discussed is IRAK4; the disease is Hypoglycemia.