APP and early-onset autosomal dominant Alzheimer disease: In an amyloid precursor protein/presenilin-1 (APP/PS1) mouse model of Alzheimer’s disease, dietary anthocyanin supplementation (12 mg/kg body weight/day) for 30 days improved performance in the Morris water maze and Y-maze task, as well as memory-related pre- and post-synaptic protein markers [30].