MAPK8 and liver cancer: Theabrownin significantly promoted the apoptosis of human melanoma cells A375 and inhibited the growth of zebrafish A375 xenograft tumors [31], and also inhibited the proliferation of Huh7 liver cancer cells by activating the Jun N-terminal Kinase pathway, as well as inhibited the tumor growth in Huh7 xenografted zebrafish [32].