ACTA1 and metabolic dysfunction-associated steatotic liver disease: Additionally, mRNA levels of α-smooth muscle actin protein (α-SMA), matrix metalloproteinase 2 (Mmp2), and tissue inhibitors of matrix metalloproteinase 2 (Timp2), shown in Figure 7F–H were significantly higher in the NAFLD mice (vs. control mice), but not in gnetin C- and RSV-supplemented mice, reflecting an imbalance in ECM protein synthesis and degradation caused by the HFCD diet.