↓ cognitive deficits, ↑ pAkt, ↑ hippocampal LTP,↑ CAT, GSH-Px, TEAC, SOD, ↓ MDA, ↓ TNF-α, IL-6, IL-1β, AGEs, cytotoxicity, ↓ the activation of microglia and astrocytes, ↓ AchE, ↑ number of neuron, ↓ MAO. The gene discussed is SOD1; the disease is Cognitive impairment.