INS and Glucose intolerance: These null findings are in contrast with our initial hypothesis that 12 weeks of LCS restriction would improve glycemic variability and other cardiometabolic biomarkers in children with T1D, which was based on results of several, mostly small trials in adults demonstrating that LCS consumption promotes glucose intolerance [32], reduces insulin sensitivity [14,15,33], disturbs the gut microbiota [17,32], and dysregulates inflammatory pathways [19].