HMGCR and tuberculosis: Meanwhile, TB not only significantly decreased P-AKT/AKT, P-GSK3β/GSK3β, P-FOXO1/FOXO1, and P-ACC/ACC ratios in cells pretreated with LY294002 compared with normal cells without inhibitors but also decreased the expression of SREBP, FASN, and HMGCR, suggesting that the effects of TB on the regulation of glucolipid homeostasis are PI3K-dependent (Figure 8).