We aimed to investigate the expression of the most common multidrug transporter genes (Breast Cancer Resistance Protein 1 (BCRP1), ATP Binding Casette Subfamily C Member 6 (ABCC6), ATP Binding Casette Subfamily B Member 1 (ABCB1), ATP Binding Casette Subfamily C Member 5 (ABCB5)) of kidney cancer in the shikonin-treated A-498 and CAKI-2 cells. This evidence concerns the gene ABCB1 and kidney cancer.